Mold-Shaped, Nanofiber Scaffold-Based Cartilage Engineering Using Human Mesenchymal Stem Cells and Bioreactor
نویسندگان
چکیده
منابع مشابه
Engineering cartilage and bone using human mesenchymal stem cells
Cartilage and bone defects are leading causes of disability. The economic burden of orthopedic repair exceeds 28 billion dollars per year in the United States alone, and the situation is similar in many other countries. Although artifi cial joints or metal inserts are widely utilized and in most cases work well, cell-based therapies based on tissue-engineered cartilage and bone beckon a new fro...
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Objective (s): The scarcity of articular cartilage defect to repair due to absence of blood vessels and tissue engineering is one of the promising approaches for cartilage regeneration. The objective of this study was to prepare an extracellular matrix derived decellularized bovine articular cartilage scaffold and investigate its interactions with seeded rat bone marrow mesenchymal stem cells (...
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The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. This review article focuses on the biology of MSCs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering...
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Bone marrow is a useful cell source for skeletal tissue engineering approaches. In vitro differentiation of marrow mesenchymal stem cells (MSCs) to chondrocytes or osteoblasts can be induced by the addition of specific growth factors to the medium. The present study evaluated the behaviour of human MSCs cultured on various scaffolds to determine whether their differentiation can be induced by c...
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Background Mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. Despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. In this clinical pilot study, we report a novel method for reconstruction ...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2008
ISSN: 0022-4804
DOI: 10.1016/j.jss.2007.12.788